These results indicate that in the anesthetized rat activation of urethral afferents by urethral perfusion can modulate the micturition reflex. Thus in patients with stress urinary incontinence, leakage of urine into the proximal urethra may stimulate urethral afferents and facil…
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Background It is suggested that the body posture during urination can influence urodynamic parameters in patients with Lower Urinary Tract Symptoms (LUTS) to an extent approaching pharmacological interventions. In this article, the influence of body position during micturition on…
A new patient operated key-pad device provided a reliably objective measure of sensations of urge during urodynamics without the need for prompting. Neuromodulation using noninvasive pudendal afferent stimulation suppressed these sensations whilst increasing bladder volume.
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Artificial intelligence (AI) has revolutionized drug discovery and development by accelerating timelines, reducing costs, and increasing success rates. AI leverages machine learning (ML), deep learning (DL), and natural language processing (NLP) to analyze vast datasets, enabling…
Machine learning methods hold the promise to reduce the costs and the failure rates of conventional drug discovery pipelines. This issue is especially pressing for neurodegenerative diseases, where the development of disease-modifying drugs has been particularly challenging. To a…
Define effects. effects synonyms, effects pronunciation, effects translation, English dictionary definition of effects. n. 1. Something brought about by a cause or agent; a result. 2. The power to produce an …
Define effects. effects synonyms, effects pronunciation, effects translation, English dictionary definition of effects. n. 1. Something brought about by a cause or agent; a result. 2. The power to produce an …
Traditionally, experimental effects on humans are investigated at the group level. In this work, we present a distributional ``spotlight'' to investigate experimental effects at the individual level. Specifically, we estimate the effects on individua...
The literature on regression kink designs develops identification results for average effects of continuous treatments (Card, Lee, Pei, and Weber, 2015), average effects of binary treatments (Dong, 2018), and quantile-wise effects of continuous treat...