Multivalent particles bind to targets via many independent ligand-receptor bonding interactions. This microscopic design spans length scales in both synthetic and biological systems. Classic examples include interactions between cells, virus binding,...
We present a simple yet accurate numerical approach to compute the free energy of binding of multivalent objects on a receptor-coated surface. The method correctly accounts for the fact that one ligand can bind to at most one receptor. The numerical...
Jul 25, 2024 · Contracts are legally binding agreements, and they pervade almost every aspect of our personal and business lives. If you own or manage a business, you've likely created or been handed …
Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression...
Positrons bind to molecules leading to vibrational excitation and spectacularly enhanced annihilation. Whilst positron binding energies have been measured via resonant annihilation spectra for $\sim$90 molecules in the past two decades, an accurate \...
i’ve been out as trans for about 4 years now and binding for about 3 1/2. When i started binding it was during the pandemic so with working from home it was super easy to bind 8hrs a day or less. Bu...
In the previous work, we investigated the correlation-induced localization-delocalization transition (LDT) of the wavefunction at band center ($E=0$) in the one-dimensional tight-binding model with fractal disorder [Yamada, EPJB (2015) 88, 264]. In t...
Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop superfamily are important neuroreceptors that mediate fast synaptic transmission. They are activated by the binding of a neurotransmitter, but the details of this process are still not ful...
In an open-bid auction, a bidder can know the budgets of other bidders. Thus, a sealed-bid auction that hides bidding prices is desirable. However, in previous sealed-bid auction protocols, it has been difficult to provide a ``fund binding'' property...
Determination of binding affinity of proteins in the formation of protein complexes requires sophisticated, expensive and time-consuming experimentation which can be replaced with computational methods. Most computational prediction techniques requir...
A method of direct solution of the Faddeev equations for the bound-state problem with zero total angular momentum is used to calculate the binding energies. The results for binding energies of He$_2$$^6$Li and He$_2$$^7$Li systems and helium atom - H...
To adapt their behaviour in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may bind nonspecifically to receptors, and when their concentration is large, this binding activi...
Within the framework of staircase infinitely deep (SIW) potential well model the effect of dielectric constant mismatch between the size-quantized semiconducting wire, coating and surrounding environment on impurity binding energy is considered. Ca...
Sep 11, 2025 · Explore how Jewish and Christian traditions interpret the Binding of Isaac (Akedah), from its biblical origins and ritual symbolism to its profound influence in art, liturgy, and interfaith thought.
Context-aware adaptation is a central aspect of pervasive computing applications, enabling them to adapt and perform tasks based on contextual information. One of the aspects of context-aware adaptation is reconfiguration in which bindings are create...
The A-site (A for aminoacyl) of a ribosome is a binding site for charged t-RNA molecules during protein synthesis. One of three such binding sites, the
We investigate the precision with which a neutron star gravitational binding energy can be measured through the supernova neutrino signal, without assuming any prior such as the energy equipartition hypothesis, mean energies hierarchy or constraints...
Summary: We introduce RBPBind, a web-based tool for the quantitative prediction of RNA-protein interactions. Given a user-specified RNA and a protein selected from a set of several common RNA-binding proteins, RBPBind computes the binding curve and e...
By mapping itinerant spin-$1/2$ fermions to four-state Fock parafermions, we construct noninteracting tight-binding models for Fock parafermions in one dimension. They have single-particle real energy spectra consisting of a sum of single-particle en...
The TATA-box Binding Protein (TBP) is required by all three eukaryotic RNA polymerases for the initiation of transcription from most promoters. TBP recognizes, binds to, and bends promoter sequences called ``TATA-boxes'' in the DNA. We present resu...