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Structural analysis of APOB variants, p.(Arg3527Gln), p.(Arg1164Thr) and p.(Gln4494del), causing Familial Hypercholesterolaemia provides novel insights into variant pathogenicity - Naturehttps://news.google.com/rss/articles/CBMiU0FVX3lxTFBUUEY4NjVsWlItd2Zzc21abE84TVF4OXY0N0hSWDJGc0pZam55MXdyRmFYbUx0c0p6OUI5TlF3RGxjT3B5b0d3R0R0V2c0QVY3aWln?oc=5Structural analysis of APOB variants, p.(Arg3527Gln), p.(Arg1164Thr) and p.(Gln4494del), causing Familial Hypercholesterolaemia provides novel insights into variant pathogenicity NatureDec 8, 2015 8:00 AM
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Forget All the Fancy Photo Gear, Here Is What a Truly Minimalistic Photographer Looks Likehttps://news.google.com/rss/articles/CBMirAFBVV95cUxOc2pJQllNbWVDdFlBcDRXZ05MV0hETWVGRGRJcDVDTnlyVnNIN01sbnRYTkd0ZUxRR0Q0dFBWZDVBcl82VE9CakQ5ZldFTlo2Yy1NVEdIRzRwQ2NqY29iQjFzR1pWcHVEUnRWVU9HT1NHbDd5dzBYN3FyMDBQLVJyNDRuTmlELUtjTktZckhlcThUQzJDRDRQc0xTUTJGc3hUWG90VllWSFY2aXVp?oc=5Forget All the Fancy Photo Gear, Here Is What a Truly Minimalistic Photographer Looks Like FstoppersDec 8, 2015 8:00 AM
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Climber Greg Boswell 'prised' grizzly's jaws off leg - BBChttps://news.google.com/rss/articles/CBMiWEFVX3lxTE5WU29VanZfTEFMSVEycnoxRV80eDRqVGtzTjlOX2cxZEVaYWJWbjE2aEZNRGZTVWtTM2ZnTVRiSGFyOUFpbHhEcU9lbVdOOFBMSDFYd0hRXzc?oc=5Climber Greg Boswell 'prised' grizzly's jaws off leg BBCDec 1, 2015 8:00 AM
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Türkan Şoray, ‘The Sultan of Turkish cinema,’ makes her comeback - Hürriyet Daily Newshttps://news.google.com/rss/articles/CBMiogFBVV95cUxPeWJnMFpETDAxWllUN3NHVEJBYWdwb3Q4Y1kwYkl2bWZrbnU2Qk1FcERIMThGNXFzMGx3Xzc4em5GUHVZNXhFcEM2TElXLXNXWEIzeEJFQm9jSlpwVS1ZSVlZOG40czNFdU9ZQnU1QVJMYnJRQ1VVQW5IeTFveG5rTVhyU1ZlN1ZER1Bnd2IyeDNLWVFlWmVITDdnTkpPdE9qdHc?oc=5Türkan Şoray, ‘The Sultan of Turkish cinema,’ makes her comeback Hürriyet Daily NewsNov 29, 2015 8:00 AM
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Ask HN: How good are the local startup scenes in Lisbon and Sofia?https://news.ycombinator.com/item?id=10638815I'm a solo founder and my startup is beginning to get some momentum. To capitalise on this I've decided it's time to move ops out of my spare bedroom and in to a more dynamic environment. Main goal for moving: increase my chances of bumping in to like minded people and finding a co-founder / first hire.I've narrowed the choice down to Lisbon or Sofia (having started with London, Paris, Barcelona, Sofia and Lisbon) and would love to hear the experiences of any HNers who have spent time in either city - especially if it was while bootstrapping your own startup (or working for someone else's)!Things I'd love to know: quality, size and diversity of local talent; quality of local accelerators and investors; how easy/hard it is to find (good) people that want to take a risk and work for an early stage startup; friendliness of the local startup scene.My pros for Sofia:- Betahaus co-working space- Fantastic cost of living (~30% cheaper than Lisbon - which itself is already cheap)- Lovely city,Nov 27, 2015 9:01 PM
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How expensive is SF rent? Use Unix commands to find outhttps://news.ycombinator.com/item?id=10597772How expensive is SF rent? Here's a coding challenge that uses Unix command line tools to find out.Hacker friends suggested I post the result and code here because I'm writing open source statistics software and this is a practical example of results and code.The results for a one bedroom in SF: mean $3348, median $3475, interquartile range $1514, and standard deviation $1130.How to use Unix commands to find out: use `curl` to fetch Craigslist apartment listings, then `sed`, `grep`, and `tr` to filter and parse the data, then `num` to calculate the statistics. curl -s http://sfbay.craigslist.org/search/sfc/apa\?min_price\=1\&bedrooms\=1 | sed 's/\(Nov 19, 2015 9:20 PM
bing.com
Good UX Is Good Business: How To Reap Its Benefitshttp://www.bing.com/news/apiclick.aspx?ref=FexRss&aid=&tid=6a8d83fddaa84c84a301b6bf1b0076db&url=https%3A%2F%2Fwww.forbes.com%2Fsites%2Fforbestechcouncil%2F2015%2F11%2F19%2Fgood-ux-is-good-business-how-to-reap-its-benefits%2F&c=17820584540163734652&mkt=en-usUser experience (UX) design focuses on enhancing user satisfaction by improving how we interact with the websites, applications and devices in our lives. In other words, UX makes complex things easy ...Nov 19, 2015 12:42 PM
bing.com
Good UX Is Good Business: How To Reap Its Benefitshttp://www.bing.com/news/apiclick.aspx?ref=FexRss&aid=&tid=6a8cb9794fc14823ab7cf99c9e75233c&url=https%3A%2F%2Fwww.forbes.com%2Fsites%2Fforbestechcouncil%2F2015%2F11%2F19%2Fgood-ux-is-good-business-how-to-reap-its-benefits%2F&c=17820584540163734652&mkt=en-usUser experience (UX) design focuses on enhancing user satisfaction by improving how we interact with the websites, applications and devices in our lives. In other words, UX makes complex things easy ...Nov 19, 2015 12:42 PM
news.google.com
Stack Overflow and the Zeitgeist of Computer Programming - Priceonomicshttps://news.google.com/rss/articles/CBMiekFVX3lxTE9FWEVLbm9iN3NLN0w5a3VUSzg4Y3BnTmxiQXhrUU1ZN1prZ0J0RzRzTklZc2FROEdCQVlXNEhEclVVWGppMlBKbEtGaGxTM3dhb0JCekF5RVB1WjlOaUNJOEJReXVfZXpiREEwV1NNdmZPNkpkQjh3U25B?oc=5Stack Overflow and the Zeitgeist of Computer Programming PriceonomicsNov 19, 2015 8:00 AM
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Minimalist Pop-up Houses in a parking garage of Bangkok - Metalocushttps://news.google.com/rss/articles/CBMihgFBVV95cUxPS2M4WmJFc2tNV19KV0F1MHZ1UjRWcld0ZWxBdVItZll2aUtUR3NudkEzX0RZcUg0ZExyRFJUZ0tleENCMmVpWUV4X0xyMVZzaWFLN1VXem9COUh3MEhtWUNZRHZkT3RINFhJWk55ZUxZamIyTFVOdjFfX2hwUDFLdHVrTThaQQ?oc=5Minimalist Pop-up Houses in a parking garage of Bangkok MetalocusNov 18, 2015 8:00 AM
news.ycombinator.com
Num command – new tool for simple statisticshttps://news.ycombinator.com/item?id=10581299http://www.numcommand.com and Twitter @NumCommandNum is a command line tool for mathematics and statistics data processing.Num can calculate sum, median, quartiles, standard deviation, and much more. Num is free open source, runs on any Unix system, and includes code libraries in Awk.The site has a tutorial, FAQ, and notes on related command line tools, R/CRAN and Python/pandas, datamash and qstats.There's a Kickstarter link if you want to fund.I'm the author and happy to answer questions about Num.Nov 17, 2015 2:43 PM
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Endangered Man Missing from Margate - NBC 6 South Floridahttps://news.google.com/rss/articles/CBMihAFBVV95cUxPbG9NMWVDUzV1bk84SDZKOUlUZ1p1NGtMLVAtNmFHcHJfRzdlSDhneEdpb3Q0WUNMWEg1aU5zY05fREl5NmNsclQxQjRzM0NLNVljSzJTVFNfYjJkOFdlN2VYQ29KX3RRQ1ZUdEVvbGtFdG5OdHpHMWsxNS1nNHY5QXdMbHfSAYwBQVVfeXFMTnhpWk1vRjN1Ml8ySXkxaVRpNXRvQWhYNnJFWEhvRHlWTWo4NzRrRzlJV1gtYXBuV1NGRWdOVTJjMjVlNWJ6U0VNZFZKX3hDekxxeVlOSi1HRFpFc3VLVkFYZksxMjZ2eGxxZW1wdGROYmZhbERvV3Y4S24tUkkzOXVKa1o4UGREZHhRMlQ?oc=5Endangered Man Missing from Margate NBC 6 South FloridaNov 15, 2015 8:00 AM
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Police Fear Missing Margate Man May Harm Himself - CBS Newshttps://news.google.com/rss/articles/CBMijAFBVV95cUxQMnV0VFlPTXNRWWdHNW1vQjBiQ3NhWWNoZkhBZjZ4TUdkSnpuVkk3Um53MjhXWExKdUpRZjNBQU1Fazc2RHJickdOblBXaFU4WEJhVlNrQXJhWFJLY3NZeGVUU1VCS2dCb05ESV8xSlNkSnYyWUVaMVpERWl1VV9MazBUeHpqc2M0Rk9jRg?oc=5Police Fear Missing Margate Man May Harm Himself CBS NewsNov 15, 2015 8:00 AM
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Meet the man who holds the future of the Internet in his hands — and thinks most security experts are “completely crazy” - The Washington Posthttps://news.google.com/rss/articles/CBMinwFBVV95cUxQSUJmdTRlMjZ6bjFaQVd2eWNuRmdNRHU1NF9BRy1fZndJSkthM0pjRFZFMVFuM21MTjMzVWlvUzdPbmoyc05nOVJkSS1hZ2ZVdFlLU09zdHdyellTZEN2YUVUcFRkQW5XNU05MjNmQjFkcGtqSnVmTGlHTG12RFFhZGs1eGZwRlpQbXkwRktLdGxTZGxZVFJDSEM0LUlITGs?oc=5Meet the man who holds the future of the Internet in his hands — and thinks most security experts are “completely crazy” The Washington PostNov 5, 2015 8:00 AM
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TAG Launches Anti-Fraud Program To Register Advertisers And Publishers - MarTechhttps://news.google.com/rss/articles/CBMilgFBVV95cUxNSGRwUXFYelVsYU9NUWVZQXVjZ1poY3E4Mks2emFfSEFFLWlydjRmOW9zLXJpVklFU3NwM2JQU2Y1SkgwMkItUm50cW8yaHlXTFE3ZHc1ZDJESnYzcmhmaVJSNWUxTVFIZmh5MmVucVFZNHNHTmxkNnhCOE5URGVIVjllX0otNnNnZTFnX21vS25tWU9RWFE?oc=5TAG Launches Anti-Fraud Program To Register Advertisers And Publishers MarTechOct 29, 2015 7:00 AM
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A Cookbook to Rehabilitate Soviet Cuisinehttps://news.google.com/rss/articles/CBMihwFBVV95cUxPSGN5bmp2LTBoT1lJUmFoQThFY2VqbkNhQm84eG1Ha0ZoTVNNdW1ELVJOUHV0QU9hWGphdFp5LWU5cy1MRjdzc2NhRkNKbEtiVlhpZEJFbXc2Xzk3dVVFTFYxVHZ2RzNPR09hWWEzZXc1eVM3YWo5eUtqMFc4ZEFiXzFsQ0xoQ2c?oc=5A Cookbook to Rehabilitate Soviet Cuisine The Moscow TimesOct 28, 2015 7:00 AM
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Why Is ‘Playboy’ Abandoning Pictures of Nude Women? - Newsweekhttps://news.google.com/rss/articles/CBMif0FVX3lxTE4wUWpEM01QLVFybFJHLThOM0gxa1pULXRiY1NreU5OSFFfeDhCS1Fpckp6dHpZTUJmT0hYVVkwY3ZtMm9kN1hhalBxQ2xTbEdnLVdUSDEzREdyMnA4Q3U5RFd3bDYyT3NxZEtNN1NxMEVmZjNsYnJTRWJoRlNEaFU?oc=5Why Is ‘Playboy’ Abandoning Pictures of Nude Women? NewsweekOct 24, 2015 7:00 AM
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PlayStation Store Has a New Wishlist Featurehttp://www.bing.com/news/apiclick.aspx?ref=FexRss&aid=&tid=6a8d5f25d7e4415c80c2ab7aa7ff0725&url=https%3A%2F%2Fwww.gamespot.com%2Farticles%2Fplaystation-store-has-a-new-wishlist-feature%2F1100-6431659%2F&c=17115118546295683051&mkt=en-usGameSpot may receive revenue from affiliate and advertising partnerships for sharing this content and from purchases through links. Sony has introduced a new Wishlist feature to the PlayStation Store, ...Oct 23, 2015 3:47 AM
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Tears and Terror: The Disturbing Final Years of Mickey Rooney - The Hollywood Reporterhttps://news.google.com/rss/articles/CBMilAFBVV95cUxPc2Q5cHpyZkMtcFJvbG5qb1NoRDlUVjdVNVprcTNWamRXUGNnMFRUQmxrMWdqaGZtUFdSdURJZHo5SVpVYm0ybFlvMWRzZ3BybzZVQ0h0QjcweFkwZU9aVUU1clZMWHpPNkJZUFNqbUVDb3FSWWwzeU5lbXNseDRqYXhoNWU1QTV3ejVuQUZLc29Edktx?oc=5Tears and Terror: The Disturbing Final Years of Mickey Rooney The Hollywood ReporterOct 21, 2015 7:00 AM
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Who is our ultimate soapie superbitch? - IOLhttps://news.google.com/rss/articles/CBMimwFBVV95cUxNTmpfakJJMnBmd0ZhbEU2WDVqRGtsY2lJUHhVdVh4RXpKcEhUTlZ0ZjlPemZzUG1URENiTWtpMGFmQ2JZXy0xSWF2SHdkODRyZENlSWpZY0JVM1NEVU1PQjFzVHZsWm9Rc2UyTS12M08tSllsNFRHY20xcDU0elNzRlVodHM0TjFxTGc1OVVjamRzenpJamtESUxQaw?oc=5Who is our ultimate soapie superbitch? IOLOct 21, 2015 7:00 AM
